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  1. 13 Because the smooth muscle of the corpus cavernosum expresses type-5 PDEs predominantly, the specificity and selectivity of PDE 5 inhibition play a crucial role in prolonging erections and in limiting adverse effects from nonspecific PDE inhibition amazon priligy

  2. cGMP signal propagation through downstream effectors leads to a decrease in the intracellular Ca 2 concentration in the corpus cavernosum smooth muscles causing smooth muscle relaxation and a reduction in arterial blood drainage and erection sustainability 16 , 39. tamoxifen alternatives

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